ICAM-2 peptides mediate lymphocyte adhesion by binding to CD11a/CD18 and CD49d/CD29 integrins

Lymphocyte adhesion mediated by integrins.

Integrins mediate adhesion to agrin and modulate agrin signaling.

Agrin, a basal lamina-associated proteoglycan, is a crucial nerve-derived organizer of postsynaptic differentiation at the skeletal neuromuscular junction. Because integrins serve as cellular receptors for many basal lamina components, we asked whether agrin interacts with integrins. Agrin-induced aggregation of acetylcholine receptors on cultured myotubes was completely blocked by antibodies t...

Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily.

The crystal structure of intercellular adhesion molecule-2 (ICAM-2) revealed significant differences in the presentation of the critical acidic residue important for integrin binding between I and non-I-domain integrin ligands. Based on this crystal structure, we mutagenized ICAM-2 to localize the binding site for the integrin lymphocyte function-associated antigen-1 (LFA-1). The integrin bindi...

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

Of the several families of adhesion receptors involved in leukocyte-endothelial cell interactions, only the selectins have been shown to initiate leukocyte interaction under physiologic shear; indeed, beta 2 (CD18) intergrins responsible for neutrophil arrest are unable to engage without prior selectin-mediated rolling. In contrast, alpha 4 (CD49d) integrins are shown here to initiate lymphocyt...

a4 Integrins Mediate Lymphocyte Attachment and Rolling under Physiologic Flow

C. Berlin, 1 R. F. Bargatze, 1, 2 j . j . Campbell,1 U. H. von Andrian, 1,3 M. C. Szabo, ~ S. R. Hasslen, 4 R. D. Nelson, 5 E. L. Berg, ~,8 S. L. Erlandsen, 7 and E. C. Butcher ~ 1Laboratory of Immunology and Vascular Biology Department of Pathology Stanford University Stanford, California 94305 and the Center for Molecular Biology and Medicine Foothill Research Center Veterans Affairs Medical ...